HMT1 — Aspergillus nidulans FGSC A4

Summary

AnHMT1 (ANIA_10526) on chromosome 2 encodes a protein with PRMT domain, arginine methyltransferase, methyltransferase, and SAM-dependent methyltransferase superfamily domains, and is annotated with histone H4KR3 methylation, protein arginine omega-N asymmetric methylase activity, protein arginine omega-N monomethylase activity, PRMT activity, histone methylase activity, ribosome binding, identical protein binding, and zinc binding. The gene is associated with protein methylation, secondary metabolism, mycotoxin biosynthesis, chromatin remodeling, regulation of transcription, mRNA nuclear export, morphogenesis, ribosome biogenesis, and membrane transport. It localizes to the cytoplasm, cytosol, and nucleus. AnHMT1 is associated with oxidative stress response and numerous phenotypes including increased sporulation and virulence, decreased lifespan, abnormal spore germination, premature cell cycle progression, altered mating efficiency, and abnormal colony color. Related genes in other species include type I protein arginine methyltransferase and EC 2.1.1.319.