CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_10613 (CLM2, AnCLM2) on Aspergillus nidulans chromosome 3 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors with oxygen incorporation. It is associated with ergosterol, terpenoid, patulin, mycotoxin, and secondary metabolite biosynthesis, as well as lipogenesis, fermentation, sexual reproduction, meiosis, endocytosis, autophagy, and hypersensitivity. The product localises to the endoplasmic reticulum membrane. Associations with numerous phenotypes include decreased micronucleophagy, nucleophagy, ribophagy, shmoo formation, ionizing radiation resistance, and invasive growth; increased cell death and fermentative metabolism; abnormal cell cycle progression, cytokinesis, and vacuolar transport; and arrested vegetative and exponential-phase growth. Related genes in other species link it to ergosterol biosynthesis.