aroM — Aspergillus nidulans FGSC A4

Summary

ANIA_10544 (symbol aroM) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a pentafunctional AROM polypeptide that possesses 3-phosphoshikimate 1-carboxyvinyltransferase, shikimate kinase, shikimate 3-dehydrogenase (NADP+), and 3-dehydroquinate dehydratase activities, and binds ATP and metal ions. The gene is associated with the shikimate pathway, aromatic amino acid family anabolism, quinate breakdown, heterotrophy, amino acid anabolism, and homeostasis. The encoded product localises to the cytoplasm. Studies of related genes in other species link the AROM family to shikimate pathway enzymes (EC 2.7.1.71, 4.2.3.4, 1.1.1.25, 2.5.1.19, 4.2.1.10) and to several Fusarium and Verticillium species.