RPF2 — Aspergillus nidulans FGSC A4

Summary

AnRPF2 (ANIA_10200) on chromosome 7 encodes a Brix domain-containing protein with ssRNA and rRNA binding activity. It is associated with ribosomal large subunit biogenesis, preribosome formation, and rRNA processing, and localizes to the nucleolus, nucleus, cytosol, and snoRNA-containing ribonucleoprotein complexes. The gene is linked to numerous phenotypes including altered cell cycle progression (delayed S phase, M phase arrest), increased resistance to ionic stress, acid pH, and desiccation, increased lifespan, altered fermentative and filamentous growth, abnormal nuclear position and fusion during mating, and changes in RNA modification and accumulation. It is also associated with nutrient utilization, redox state, and small molecule transport. Related genes in other species link it to ribosome assembly factors such as RRS1, BUD20, and TIF6.