CTA4 — Aspergillus nidulans FGSC A4

Summary

AnCTA4 (CTA4) on chromosome 6 of Aspergillus nidulans encodes a P5A-type ATPase, a member of the P-type ATPase ion transporter family with E1-E2 ATPase and cation-transporting ATPase activity, including manganese and calcium transporter activity. It is associated with extraction of mislocalized protein from the ER membrane, monoatomic cation transmembrane transport, manganese and calcium ion homeostasis, response to unfolded protein, macroautophagy, hyphal growth, spore formation, and cell division. The protein localizes to the ER membrane, nuclear envelope, Golgi membrane, fungal-type vacuole membrane, and plasmalemma. Phenotypic associations include altered fermentative and anaerobic growth, increased freeze-thaw and hydrostatic pressure resistance, abnormal colony shape and septum formation, decreased nucleophagy and micronucleophagy, and increased aneuploidy. Studies of related genes in other species link the family to oxidative stress response, acid sensitivity, and reduced virulence.