SED5 — Aspergillus nidulans FGSC A4

Summary

AnSED5 (ANIA_09526) on chromosome 3 of Aspergillus nidulans encodes a syntaxin-5 family SNARE protein, specifically the ER-Golgi SNARE complex subunit Sed5. As a SNARE, it is associated with vesicle fusion at the Golgi apparatus, ER-to-Golgi transport, intra-Golgi transport, cisternal maturation, exocytosis, vacuole fusion, and hyphal growth. The protein localises to the cis-Golgi network, Golgi membrane, SNARE complex, and endomembrane system. AnSED5 has been linked to abnormal carbon and nitrogen source utilisation, absent protein transport and flocculation, decreased cell cycle progression, abnormal Golgi and vacuolar morphology, defective prion inheritance, and absent innate thermotolerance. It is also connected to decreased entry into G0, increased nutrient uptake, and abnormal endocytosis.