atrR — Aspergillus nidulans FGSC A4

Summary

ANIA_09516 (atrR) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor, a member of the AtrR-like family with sequence-specific DNA-binding and RNA polymerase II-specific transcription factor activity. The gene is associated with positive regulation of metabolism and transcription, ergosterol anabolism, biofilm formation, and hypersensitivity. Its product localises to both the nucleus and membrane. Related genes in other species are linked to reduced virulence and pulmonary aspergillosis in mouse models, though these associations are not yet established for this specific gene.