ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_09344, also known as AnABCA, encodes an ABC multidrug transporter with ATP hydrolase activity and ATP binding capability. This plasma membrane protein is associated with xenobiotic detoxification by transmembrane export, response to toxic substances, demethylation, homologous recombination, and hypersensitivity. The gene has been linked to numerous phenotypes including abnormal replicative and chronological lifespan, increased sporulation rate, decreased cell death, premature endocytosis, delayed mitophagy, abnormal pseudohyphal growth, decreased meiosis, abnormal spore wall formation, and altered cell cycle progression through G1/S phase transition. It is also connected to changes in nutrient uptake, vesicle distribution, plasma membrane morphology, and radiation resistance. Studies of related genes in other species link the family to virulence and pathogenicity, as well as to traits including drought tolerance, plant height, and root length.