uncA — Aspergillus nidulans FGSC A4

Summary

ANIA_09122 (uncA) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a protein with a BD-FAE-like domain, a Peptidase_S9 domain, and an AB_hydrolase domain, placing it in the GDXG lipolytic enzyme family. The gene product exhibits serine-type peptidase activity, ketoacyl-ACP synthase activity, fatty acid synthase activity, phosphopantetheine binding, methyltransferase activity, and hydrolase activity. It is associated with primary growth, hyphal growth, mitosis, microtubule-based transport, microtubule shortening, nuclear transport, nuclear import, exocytosis, endocytosis, vesicle transport, proteolysis, methylation, and the biosynthesis of fatty acids, antibiotics, cichorine, terpenoids, and other secondary metabolites. Studies of related genes in other species link the family to additional metabolic functions, though these associations are not yet established in A. nidulans.