hxnS — Aspergillus nidulans FGSC A4

Summary

ANIA_09178 (hxnS) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes a protein with xanthine dehydrogenase activity, FAD binding, 2Fe-2S cluster binding, protein homodimerization activity, and redox activity. The gene is associated with the breakdown of hypoxanthine, xanthine, guanine, nicotinate, and purine bases, as well as cellular responses to ammonia, nitrate, iron, zinc, copper, and cadmium. The encoded protein localises to the peroxisome and cytoplasm. Related genes in other species, including Fusarium oxysporum strains, are linked to xanthine dehydrogenase activity (EC 1.17.1.4), though these associations are not established for hxnS itself.