GMTA — Aspergillus nidulans FGSC A4

Summary

AnGMTA (ANIA_09298) on chromosome 8 encodes a GDP-mannose transmembrane transporter with antiporter activity, belonging to the SCL35B1-4/HUT1 and TPT_transporter families. It is localized to the Golgi membrane, endoplasmic reticulum membrane, and cytoplasmic vesicle membrane. The gene is associated with GDP-mannose transmembrane transport, spore germination, cell adhesion, biofilm formation, sporulation, morphogenesis, cell growth, and membrane transport. Phenotypic associations include decreased spore germination, increased biofilm formation, abnormal sporulation, decreased survival rate in stationary phase, decreased ionic stress resistance, decreased alkaline pH resistance, increased flocculation and pseudohyphal growth, increased autophagy, abnormal endomembrane system and mitochondrial morphology, decreased telomere length, and altered cell cycle progression with G1 phase arrest. Studies of related genes in other species link the family to nitrogen source utilization.