DLH1 — Aspergillus nidulans FGSC A4

Summary

AnDLH1 (ANIA_09092) on chromosome 6 of Aspergillus nidulans encodes a meiotic recombination protein (Dmc1) with recombinase activity, ATP hydrolase activity, and Sae3-Mei5 complex binding. It contains RecA and Rad51 domains. The gene is associated with meiotic strand invasion, double-strand break repair involved in meiotic recombination, meiotic prophase I, and recombinational interstrand cross-link repair. It is linked to meiotic chromosome organization, DNA recombinase assembly, and stalled replication fork localization to the nuclear periphery. Phenotype associations include absent sporulation efficiency, absent X-ray resistance, absent mitotic recombination, and abnormal spore germination. The protein localizes to the nucleus, condensed nuclear chromosome, site of double-strand breaks, and nucleolus. Related genes in other species link the family to meiotic recombination.