SOR1 — Aspergillus nidulans FGSC A4

Summary

AnSOR1 (ANIA_09064) on chromosome 6 of Aspergillus nidulans FGSC A4 encodes an L-iditol 2-dehydrogenase (NAD+) with D-xylulose reductase activity (EC 1.1.1.9), belonging to the SDH-like and ADH-like protein families and binding zinc. The gene is associated with D-xylose metabolism, xylitol breakdown to xylulose 5-phosphate, sorbitol breakdown, fructose anabolism, xanthine and urate transport, and localises to the cytosol. Phenotypic associations include increased fermentative growth, decreased anaerobic growth rate, decreased respiratory growth, altered chemical compound accumulation and excretion, decreased hyperosmotic and oxidative stress resistance, altered competitive fitness, decreased vegetative growth rate, increased chronological lifespan, and auxotrophy. Studies of related genes in other species link the family to xylitol dehydrogenase activity.