ACUD — Aspergillus nidulans FGSC A4

Summary

AnACUD (ANIA_08755) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes an isocitrate lyase with methylisocitrate lyase activity (EC 4.1.3.30) and metal binding capacity, belonging to the ICL/PEPM family and containing a pyruvate kinase-like domain. The gene is associated with the glyoxylate cycle, gluconeogenesis, acetate metabolism, catabolite repression, the TCA cycle, and morphogenesis, and its product localises to the glyoxysome and mitochondrial lumen. AnACUD has been linked to decreased vegetative growth rate, abnormal cell cycle progression, altered RNA accumulation, increased toxin and chemical resistance, decreased competitive fitness, and inviability. Related genes in other species are associated with reduced virulence.