BD — Aspergillus nidulans FGSC A4

Summary

ANIA_08868 (AnBD) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes the Rheb small monomeric GTPase RhbA, a member of the Ras-type small GTPase family. The protein exhibits GDP and GTP binding, GTPase activity, and protein serine/threonine kinase activator activity. AnBD is associated with small GTPase-mediated signal transduction, Ras protein signal transduction, and upregulation of TORC1 signaling. It is linked to the negative regulation of asexual sporulation, conidium formation, spore germination, and mating-type switching, as well as cellular responses to nitrogen starvation, activation of L-arginine uptake, and mycose catabolism. The protein localizes to the plasma membrane, endomembrane system, cytosol, and nucleus. Phenotypic associations include altered vacuolar transport, bipolar budding pattern, redox state, osmotic and oxidative stress resistance, cell cycle progression, and prion inheritance. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.