ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_08928, designated AnABCA, encodes an ABC transporter with ATP hydrolase and ATP-binding activities. This plasma membrane protein is associated with xenobiotic detoxification via transmembrane export, demethylation, homologous recombination, and hypersensitivity responses. AnABCA has been linked to numerous cellular processes including abnormal small molecule transport, altered vacuolar distribution and transport, increased sporulation rate, decreased cell death, delayed mitophagy, abnormal replicative and chronological lifespan, aberrant pseudohyphal growth, and cell cycle arrest at the G1/S transition. The gene also connects to nutrient uptake abnormalities, delayed chemical compound accumulation, and altered fermentative growth and metabolism. Studies of related genes in other species link the family to reduced virulence, though this association is not established for AnABCA itself.