gal4 — Aspergillus nidulans FGSC A4

Summary

ANIA_08930 (gal4) on chromosome 7 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. The gene is associated with positive regulation of thiamin biosynthetic process, nitrate assimilation, and upregulation of transcription by galactose. It has been linked to aflatoxin and sterigmatocystin anabolism, RNA-dependent gene silencing, and general positive regulation of metabolism. The product localises to the nucleus, cytoplasm, and membrane. Related genes in other species are linked to reduced virulence and pulmonary aspergillosis.