CUT1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08783 (symbol CUT1, also known as AnCUT1) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a protein containing a Peptidase_C50 domain and a SEPARIN_core domain, with thiol endopeptidase activity. The gene is associated with mitotic and meiotic chromosome separation, maintenance of sister chromatid cohesion, nuclear division, cytokinesis, sporulation, cell cycle control, DNA damage response, DNA replication, proteolysis, and lipid metabolism. The encoded product localises to the Cut1-2 complex, mitotic spindle midzone, mitotic spindle, mitotic spindle pole body, cytoplasm, cytosol, and nucleus. Related genes in other species link the family to EC 3.4.22.49 (separase activity).