TPS1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08639 (symbol TPS1, also known as AnTPS1) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes the synthase subunit of the trehalose-6-phosphate synthase/phosphatase complex, a member of the Glyco_trans_20 family with trehalose synthase, trehalose-phosphatase, transglucosylase and nucleotide-binding activities. The gene is associated with mycose (trehalose) biosynthesis and metabolism, cellular responses to desiccation, heat, hydrogen peroxide and general stress, catabolite repression, filamentous growth, ascospore formation, secondary metabolism and nitric oxide storage. It localises to the trehalose-6-phosphate synthase complex, cytosol and nucleus. Associations include increased acquired thermotolerance, abnormal spore germination, absent biofilm formation and desiccation resistance, increased freeze-thaw resistance, decreased hypoosmotic stress resistance, and altered cell cycle progression, pheromone sensitivity, nitrogen utilisation and fermentative growth. Related genes in other species are linked to reduced virulence and oxidative stress responses.