gal4 — Aspergillus nidulans FGSC A4

Summary

ANIA_08590 (gal4) on chromosome 3 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor with DNA-binding transcription activator activity specific to RNA polymerase II. The gene is associated with upregulation of pyrimidine-containing compound salvage, positive regulation of patulin anabolism, upregulation of transcription from RNA polymerase II promoter by galactose, nitrate assimilation, aflatoxin anabolism, sterigmatocystin anabolism, and positive regulation of metabolism. The encoded protein localises to the nucleus, cytoplasm, cytosol, chromatin, and the mitotic spindle. Studies of related genes in other species link the family to patulin biosynthesis (patL) and to FDB cluster proteins, though these associations are not yet established for this species.