ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_08489 (ABCA, AnABCA) on Aspergillus nidulans chromosome 5 encodes an ABC transporter of the ABCG/PDR family, with ATP hydrolase and ATP-binding activities. The gene is associated with demethylation, homologous recombination, and hypersensitivity, and its product localises to the plasma membrane. AnABCA is linked to numerous cellular processes including small molecule transport, vacuolar distribution and transport, sporulation rate, cell death, cell cycle progression, endocytosis, mitophagy, replicative and chronological lifespan, pseudohyphal growth, shmoo formation, and bipolar budding pattern. Associations also include altered nutrient uptake, alkaline pH resistance, chemical compound accumulation, cell fusion, exit from G0, fermentative growth and metabolism, respiratory metabolism, meiotic recombination, vesicle distribution, and protein activity. Studies of related genes in other species connect the family to multidrug resistance and traits such as drought tolerance, plant height, and root length.