AIF1 — Aspergillus nidulans FGSC A4

Summary

AnAIF1 (ANIA_08525) on chromosome 5 of Aspergillus nidulans encodes a protein with electron-transferring-flavoprotein dehydrogenase activity and FAD/NAD-binding domains, localising to the mitochondrial membrane and outer membrane. It is associated with apoptotic mitochondrial changes, negative regulation of ferroptosis, upregulation of apoptosis, cell death, autophagy, mating type switching, meiosis, and mating. Phenotypic associations include increased or decreased apoptosis, delayed or arrested mitotic cell cycle, increased necrotic cell death, increased respiratory metabolism, altered fermentative metabolism, abnormal spindle pole body position, cytoskeleton morphology, nuclear position, and nucleolar morphology, as well as decreased cold sensitivity, altered prion formation and loss, decreased mutation frequency, and abnormal RNA localisation. Studies of related genes in other species link the family to increased viability and oxidative stress resistance.