ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_08344 (ABCA, AnABCA) on chromosome 5 of Aspergillus nidulans FGSC A4 encodes an ABCG-type transporter with ATP hydrolase activity and ATP binding, belonging to the PDR/CDR family. The gene is associated with zearalenone biosynthetic process, demethylation, response to toxic substances, and xenobiotic detoxification by transmembrane export across the plasma membrane. It localises to the vacuolar membrane and plasmalemma. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death, delayed exit from G0, increased fermentative growth, abnormal chronological and replicative lifespan, and altered nutrient uptake. Studies of related genes in other species link the family to plant height, root length, drought tolerance, and reduced virulence.