CLM2 — Aspergillus nidulans FGSC A4

Summary

ANIA_08358 (symbol CLM2, also known as AnCLM2) on Aspergillus nidulans chromosome 5 encodes a cytochrome P450 monooxygenase of the fungal cytochrome P450 family, with heme and iron binding and oxidoreductase activity acting on paired donors with oxygen incorporation. The gene is associated with ergosterol, terpenoid, patulin, mycotoxin and secondary metabolite biosynthesis, as well as lipogenesis, fermentation, sexual reproduction, meiosis, endocytosis, autophagy and hypersensitivity. It is linked to the endoplasmic reticulum membrane. Phenotypic associations include decreased micronucleophagy, ribophagy and nucleophagy, increased cell death, cell cycle progression through G2/M, and fermentative metabolism, along with abnormal plasma membrane morphology, cytokinesis, and vegetative growth arrest. Studies of related genes in other species connect the family to sterol biosynthesis and protein content.