PYR4 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene PYR4 (ANIA_08380) on chromosome 5 encodes a PaxB-like protein with lyase activity. The gene is associated with aflatoxin metabolism and anabolism, terpenoid anabolism, DNA modification and integration, homologous and mitotic recombination, gene conversion, asexual sporulation, spore formation, morphogenesis, regeneration, and digestion. Its product is localized to the membrane. Studies of related genes in other species link the PaxB family to the enzyme class 4.2.3.- and to oxidative stress response. Sequence similarity also connects the family to proteins from Verticillium dahliae and several Fusarium pathogens.