KIP2 — Aspergillus nidulans FGSC A4

Summary

ANIA_08286 (KIP2, kipA) encodes a kinesin motor domain protein with microtubule plus-end polymerase activity, plus-end-directed microtubule motor activity, microtubule binding, and ATP hydrolase activity. It is associated with microtubule dynamics, stabilization, and organization, as well as mitotic spindle elongation, chromosome movement, nuclear migration, and apical protein localization. The gene is linked to cell cycle progression, including delayed or arrested mitotic cell cycle, abnormal anaphase and telophase timing, increased polyploidy and aneuploidy, and abnormal sporulation, septum formation, and mating projection morphology. It localizes to microtubule ends, the kinesin I complex, cortical microtubule plus-ends, and the spindle midzone.