PMA1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08219 (PMA1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a plasma membrane proton P-type ATPase, a member of the P-type ATPase family with ATP hydrolase activity and the ability to bind protons, calcium, and manganese. The gene is associated with proton export across the plasma membrane, cell pH regulation, and transmembrane transport of protons, calcium, and manganese, as well as cellular ion homeostasis for calcium and manganese. It has been linked to cephalosporin C anabolism, macroautophagy, fungal-type cell wall organization, and fermentation. The product localizes to lipid rafts, extracellular vesicles, Golgi, ER, nuclear envelope, and cell tips or division sites. Studies of related genes in other species link the PMA1 family to reduced virulence and loss of pathogenicity, with associations to diseases such as pulmonary aspergillosis and fusarium head blight.