HSC82 — Aspergillus nidulans FGSC A4

Summary

ANIA_08269 (HSC82, AnHSC82) on Aspergillus nidulans chromosome 2 encodes a heat shock protein 90 (Hsp90) family member, an ATP-dependent protein folding chaperone with ATP hydrolase and ATP binding activities. The gene is associated with protein folding, stabilization, and cellular response to heat, as well as cyclosome assembly, ciliogenesis, intracellular steroid hormone receptor signaling, cell migration, box C/D snoRNP assembly, regulation of apoptotic process, multidomain protein assembly, inflammatory response, proteasome assembly, filamentous growth, nuclear movement, anaphase, and cell cycle modulation. It localizes to the perinuclear cytoplasm, hyphal cell wall, cross wall, extracellular vesicles, mitochondria, and plasmalemma. Phenotypic associations include altered cell cycle progression, increased thermotolerance, abnormal spore germination, decreased hypoosmotic stress resistance, premature apoptosis, absent biofilm formation, and abnormal flocculation. Studies of related Hsp90 family members in other species link the family to reduced virulence and oxidative stress response.