NRD1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08276 (symbol NRD1, also known as AnNRD1 or AnSEB1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a putative RNA-binding protein Nrd1. The product contains RNA recognition motif (RRM), CID, and ENTH/VHS domains, and is annotated with RNA polymerase II C-terminal binding, lncRNA binding, snoRNA binding, and phase separation nucleator activities. It localises to the nucleus and spliceosome complex. The gene is associated with regulatory ncRNA and sno(s)RNA 3′-end processing, mRNA 3′-end processing, cotranscriptional 3′ processing of RNA polymerase II transcripts, negative regulation of gene expression, centromeric silencing, RNA splicing, secondary metabolism, glycerol anabolism, and osmotic response. Phenotypic associations include decreased cell cycle progression through G2/M, delayed exit from G0, decreased colony size, increased ionic stress resistance, increased acquired thermotolerance, decreased anaerobic growth, and altered RNA modification and protein secretion. Related genes in other species link the family to RNA 3′-end processing and chromatin silencing.