HAPX — Aspergillus nidulans FGSC A4

Summary

ANIA_08251 (HAPX) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a bZIP transcription factor that binds RNA polymerase II cis-regulatory regions and acts as a DNA-binding transcription activator. This gene is associated with the downregulation of iron ion transport, siderophore metabolism, and cellular iron ion homeostasis, as well as the inhibition of asperthecin and sterigmatocystin formation, and the upregulation of cellular response to amino acid starvation. It is linked to ferricrocin and heme anabolism, reductive iron assimilation, and both asexual and sexual sporulation. The encoded protein localises to the nucleus, cytoplasm, and transcription regulator complexes. Related genes in other species are linked to oxidative stress response and reduced virulence.