PYR4 — Aspergillus nidulans FGSC A4

Summary

ANIA_08144 (PYR4, AnPYR4) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a PaxB-like integral membrane protein with lyase activity. The gene is associated with terpenoid anabolism, including paxilline and aflatoxin metabolism, as well as DNA modification, integration, gene conversion, mitotic and homologous recombination, regeneration, digestion, asexual sporulation, spore formation, and morphogenesis. It is linked to membrane localisation. Related genes in other species, including PaxB, olcD, cle7, janB, atmB, esdpB, and ptmB, connect the family to oxidative stress response, and sequence similarity links the gene to plant pathogens such as Verticillium dahliae and Fusarium oxysporum pathovars.