ASPC — Aspergillus nidulans FGSC A4

Summary

ANIA_08182 (ASPC, AnASPC) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a septin-type G domain-containing protein with GTPase activity and GTP binding, and is a structural constituent of the cytoskeleton. It also binds phosphatidylinositol phosphates and lipids. The gene is associated with numerous cell cycle processes including cytokinesis, septin ring assembly and disassembly, contractile ring assembly, and the G1/S transition. It is linked to chitin localization, ER polarization, nuclear movement, and chlamydospore formation. Phenotypic associations include delayed cytokinesis, abnormal filamentous growth, decreased spore germination rate, and altered cell cycle progression through G2/M. The gene product localizes to the septin cytoskeleton, septin complexes, and the ascospore wall. Studies of related genes in other species link the family to altered virulence.