gliT — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene gliT (ANIA_08218) on chromosome 2 encodes a putative thioredoxin reductase with NADPH activity, featuring ferredoxin-NADP reductase-like structure. This gene is associated with gliotoxin anabolism and its regulation, as well as kojic acid anabolism. It is linked to cellular response to mycotoxin, cellular response to toxic substance, cell redox homeostasis, detoxification, secretion, autolysis, and cell death. The encoded protein is localized extracellularly. Related genes in other species, such as Fusarium oxysporum and Verticillium dahliae, are linked to similar redox and detoxification processes, though these associations are not yet established for A. nidulans itself.