CLM2 — Aspergillus nidulans FGSC A4

Summary

AnCLM2 (ANIA_08078) on chromosome 2 of Aspergillus nidulans encodes a phenylacetate 2-hydroxylase, a cytochrome P450 family protein with monooxygenase activity, heme and iron binding, and 3-hydroxyphenylacetate 6-hydroxylase activity. The gene is associated with phenylacetate breakdown, penicillin anabolism, ergosterol anabolism, lipogenesis, sexual reproduction, meiosis, fermentation, endocytosis, and autophagy. It is linked to numerous phenotypes including decreased micronucleophagy and ribophagy, increased cell death, arrested vegetative and exponential-phase growth, abnormal cell cycle progression through the G2/M phase transition, decreased shmoo formation, and increased lifespan. The gene product localizes to the membrane. Studies of related genes in other species link the family to ergosterol biosynthesis.