SOR1 — Aspergillus nidulans FGSC A4

Summary

ANIA_08109 (SOR1) in Aspergillus nidulans FGSC A4 encodes a D-xylulose reductase with L-iditol 2-dehydrogenase (NAD+) activity (EC 1.1.1.9) and zinc binding capability, belonging to the SDH-like and ADH-like protein families. The gene is associated with D-xylose metabolism and breakdown, xylitol breakdown to xylulose 5-phosphate, sorbitol breakdown, fructose anabolism, and xanthine and urate transport, and its product localises to the cytosol. Phenotypic associations link SOR1 to increased fermentative growth, decreased anaerobic growth rate, decreased carbon and nitrogen source utilisation, decreased hyperosmotic and oxidative stress resistance, altered chemical compound accumulation and excretion, increased chronological lifespan, altered competitive fitness, and decreased vegetative growth rate. Related genes in other species connect the family to xylitol dehydrogenase activity.