lox — Aspergillus fumigatus

Summary

AFU7G06810 (symbol lox) on chromosome 7 of Aspergillus fumigatus encodes L-amino acid oxidase LaoA, a flavin monoamine oxidase with L-amino-acid oxidase activity (EC 1.4.3.2). The gene is associated with amino acid breakdown, arachidonic acid metabolism, eoxin synthesis, and ochratoxin A anabolism. It is linked to cytokine production (including CCL4, IL-10, IL-22, and IL-1), inflammatory response, innate immunity, angiogenesis, lymphangiogenesis, cell motility, quorum sensing, sensitization, bioluminescence, and vision. Associations with flavonoid content have also been noted.