CLM2 — Aspergillus fumigatus

Summary

AFU8G00220 (CLM2, also known as ftmE) on chromosome 8 of Aspergillus fumigatus encodes a cytochrome P450 with oxidoreductase activity, classified as EC 1.14.19.71, and is associated with heme and iron binding. The gene is associated with sterol homeostasis, demethylation, and fatty acid oxidation, as well as with processes including asexual reproduction, sporulation, mitochondrial fission, and actin depolymerization. Phenotypic associations connect CLM2 to decreased vegetative and invasive growth, increased cell death, abnormal cell cycle progression, reduced nutrient uptake, and decreased resistance to ionizing radiation. The gene is also associated with abnormal plasma membrane morphology, decreased vacuolar transport, and increased fermentative metabolism. Studies of related genes in other species link the family to sterol biosynthesis.