prx1 — Aspergillus fumigatus

Summary

AFU8G00280 (symbol prx1) on chromosome 8 of Aspergillus fumigatus encodes a putative short-chain dehydrogenase of the SDR family, with NAD(P)-binding and redox activity. The gene is associated with terpenoid anabolism, translation elongation, and cytoskeleton organization, and its product localizes to the membrane. It is associated with the oxidative stress response and with response to fungi. Studies of related genes in other species connect the family to additional short-chain dehydrogenase/reductase activities (EC 1.1.1.-, 1.1.99.-) and to the biosynthesis of compounds such as DRIM-7-ENE-11, fscI, and calI, though these functions are not established for prx1 itself.