sdeA — Aspergillus fumigatus

Summary

AFU8G00590 (symbol sdeA) in Aspergillus fumigatus chromosome 8 encodes a fatty acid desaturase domain-containing protein with cytochrome b5-like heme/steroid-binding features and EC 1.14.19.18 oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen. The gene is associated with unsaturated fatty acid metabolism, glucosylceramide anabolism, sphingolipid metabolism, fatty acid metabolism, and lipid metabolism, as well as plasma membrane organization. It is linked to membrane localisation. Studies of related genes in other species connect the family to delta 8-(E)-sphingolipid desaturase activity, though this specific function is not established for sdeA itself.