cat2 — Aspergillus fumigatus

Summary

AFU8G01670, designated cat2 in Aspergillus fumigatus on chromosome 8, encodes a catalase-peroxidase (EC 1.11.1.21) with catalase and peroxidase activities, heme binding, and metal binding. This haem peroxidase family member is associated with detoxification of hydrogen peroxide, the cellular response to hydrogen peroxide, and the H₂O₂ catabolic process. It is also linked to autolysis, asexual sporulation, and sporulation, and localises to the cytosol. The gene has been connected to oxidative stress response. Studies of related genes in other species link the catalase-peroxidase family to oxidative stress tolerance, though these associations are not yet established for A. fumigatus.