CGR1 — Aspergillus fumigatus

Summary

AFU8G02750 (CGR1, cgrA) in Aspergillus fumigatus encodes a Cgr1-like domain protein. This gene is associated with ribosome biogenesis, rRNA processing, and protein synthesis, and its product localises to the nucleolus. It is linked to polar cell growth, morphogenesis, and cell growth, as well as to inflammatory and immune responses. Associations with aspergillosis and with Mus musculus have also been noted. Phenotypic associations include effects on vegetative growth, cytokinesis, nutrient uptake, respiratory and fermentative metabolism, RNA modification and accumulation, chitin deposition, desiccation and osmotic stress resistance, nuclear export, mitotic recombination, apoptosis, and utilisation of carbon and nitrogen sources. Studies of related genes in other species, such as RRS1 in mouse and IKI3 and SIT4 in human, connect the family to ribosome assembly and cell cycle regulation.