zfpA — Aspergillus fumigatus

Summary

AFU8G05010 (symbol zfpA, also known as C2H016) on chromosome 8 of Aspergillus fumigatus encodes a C2H2 zinc-finger domain protein that binds zinc and is predicted to localise to the nucleus. The gene is associated with the regulation of transcription by RNA polymerase II and DNA-dependent transcription. Annotated biological process associations include 1,3-beta-glucan anabolism, chitin anabolism, hyphal growth, and innate immunity/immune response. Related genes in other species are linked to altered virulence, with some relatives showing reduced virulence, hypervirulence, or unaffected pathogenicity; these family members have also been connected to pulmonary aspergillosis and invasive pulmonary aspergillosis.