ZRT1 — Aspergillus fumigatus

Summary

AFU1G01550 (ZRT1, also known as zrfA) encodes a high-affinity zinc ion transporter belonging to the ZIP family, with high-affinity zinc transmembrane transporter activity, zinc ion transmembrane transporter activity, and zinc binding. The gene is associated with response to zinc, zinc transport, zinc import, zinc ion membrane transport, cellular response to pH, gliotoxin anabolism, cellular zinc ion homeostasis, response to oxidative stress, ergosterol anabolism, and homeostasis. The transporter localises to the plasma membrane and ER membrane. ZRT1 is linked to invasive pulmonary aspergillosis and has been connected to numerous phenotypes including abnormal sporulation efficiency, delayed sporulation, absent spore germination, decreased radiation resistance, increased pseudohyphal growth, decreased apoptosis, altered cell cycle progression, and increased mitophagy. Related genes in other species link the family to iron concentration and normal vegetative growth.