ERG-3 — Aspergillus fumigatus

Summary

AFU1G03150 (ERG-3) encodes a protein with a Sterol_reductase_CS domain and an ERG24_DHCR-like domain, and has D14-sterol reductase activity and NADP binding. The gene is associated with ergosterol and sterol anabolism, and its product localises to the endoplasmic reticulum membrane. ERG-3 is associated with hyphal growth, filamentous growth in response to biotic stimuli, cellular response to xenobiotic stimulus, and homeostasis. It is also linked to numerous phenotypes including abnormal plasma membrane morphology, decreased spore germination, increased cell death, and altered vacuolar transport, as well as traits such as salt tolerance. Studies of related genes in other species link the family to reduced virulence and invasive pulmonary aspergillosis.