TRR1 — Aspergillus fumigatus

Summary

AFU1G05100 (AfTRR1) on Aspergillus fumigatus chromosome 1 encodes a putative GARP complex subunit Vps53, a protein containing Vps53_N and Vps53_C domains. The gene is associated with Golgi-to-vacuole transport, retrograde endosome-to-Golgi transport, and intracellular protein transport. It is linked to the GARP complex, endosome membrane, cytoplasm, and cytosol localization. Annotated associations include responses to basic pH and iron, as well as oxidative stress response. Phenotypic connections involve altered cell cycle progression (increased G2/M transition rate, decreased S phase), abnormal colony color, increased aneuploidy, decreased radiation resistance, increased mutation frequency, altered nutrient uptake, and increased survival in stationary phase. Studies of related genes in other species link the family to thioredoxin reductase and FAD/NAD-binding domains, though these functions are not established for AfTRR1.