SOD2 — Aspergillus fumigatus

Summary

AFU1G07170 (SOD2) on Aspergillus fumigatus chromosome 1 encodes a putative Na/H antiporter belonging to the Na+/H+_antiporter_fungi family, with potassium:proton antiporter activity, sodium:hydrogen exchanger activity, and potassium transporter activity. It is associated with sodium ion membrane transport, cellular sodium and potassium ion homeostasis, proton export across the plasma membrane, regulation of membrane potential, cell pH reduction, and sodium ion export from the cell. The gene has also been connected to hyphal growth, detoxification, hypersensitivity, calcium signaling, glutathione metabolism, D-amino acid metabolism, nucleotide metabolism, homologous recombination, MMR, NO storage, and oxidative stress response. The product localizes to the plasma membrane (including cell tips), perinuclear ER membrane, nuclear membrane-ER network, and FSM. Studies of related Na+/H+ antiporters in other species link the family to similar ion transport functions.