rglT — Aspergillus fumigatus

Summary

AFU1G09190 (symbol rglT) on chromosome 1 of Aspergillus fumigatus encodes a DNA-binding transcription factor with a Zn2Cys6 DNA-binding domain and a stress response regulator domain. The protein localises to the nucleus and is associated with the regulation of gliotoxin anabolism, kojic acid anabolism, ubiquinone anabolism, sulfur metabolism, detoxification, secretion, cell death, immune evasion, and positive regulation of transcription by RNA polymerase II. It is also linked to pulmonary aspergillosis and has been studied in Mus musculus. The gene is associated with DNA-dependent transcription. Related genes in other species, such as Q5BDL2 and CBF87636, are linked by sequence similarity.