ERG25 — Aspergillus fumigatus

Summary

AFU1G11140 (ERG25) in Aspergillus fumigatus encodes a sterol desaturase-related protein with a fatty acid hydroxylase domain, possessing 4-methylsterol oxidase activity, iron binding, and redox activity. This protein is localized to the ER membrane and is associated with demethylation, sterol homeostasis, sterol anabolism, ergosterol anabolism, mating, and homeostasis. Studies of related genes in other species link the family to similar sterol desaturase functions, though these associations are not established for this specific gene.