TUL1 — Aspergillus fumigatus

Summary

AFU1G12080 (TUL1, dscA) in Aspergillus fumigatus encodes a RING-type E3 ubiquitin ligase (EC 2.3.2.27) with zinc-binding activity, containing DUF2921 and HRD1_E3_ubiq-ligase domains. It is a component of the Dsc E3 ubiquitin ligase complex and localises to the Golgi membrane, ER membrane and endomembrane system. The gene is associated with ubiquitin-dependent protein catabolism via the MVB pathway, SREBP signalling, hyphal growth, and proteasomal proteolysis. Annotated associations link TUL1 to altered cell cycle progression, increased vegetative growth, decreased spore germination, reduced osmotic stress resistance, abnormal autophagy and mitophagy, and impaired vacuolar transport, endocytosis and protein secretion. Studies of related genes in other species connect the family to defective SREBP cleavage and killer toxin resistance, while sequence similarity links the family to oxidative stress response.