CUL1 — Aspergillus fumigatus

Summary

AFU1G12960 (symbol CUL1, also known as AfCUL1) encodes a putative cullin-family protein that is annotated with ubiquitin ligase complex scaffold activity, ligase activity, ubiquitin ligase binding, and inositol hexakisphosphate binding. In Aspergillus fumigatus, this gene is associated with protein ubiquitination, the proteasomal pathway, DNA damage response, cell division, DNA-dependent transcription, dephosphorylation, and degradation of meiosis-specific transcripts. It is also linked to RNAi-mediated heterochromatin assembly at centromeres, centromeric silencing, telomeric silencing, and silencing of silent mating-type cassettes. The encoded protein localizes to the nucleus, cytosol, Cul4-RING E3 ubiquitin ligase complex, and heterochromatin regions including centric, subtelomeric, and mating-type region heterochromatin. Associations with oxidative stress response, cell cycle progression, mating efficiency, biofilm formation, flocculation, sporulation, and pseudohyphal growth have been observed. Studies of related genes in other species link the family to the nuclear SCF complex.